Autor(es): Uribe S M Reinaldo, Suárez H Felipe, Sandoval R Patricio, Mellado T Patricio

Resumo: Anti-GQ1b syndrome includes Miller Fisher Syndrome (MFS), Guillain Barré Syndrome (GBS), Bicker staff`s brain stem encephalitis (BBE) and Acute Ophtamoplegia (AO). We report four patients aged 16 to 76 years, with anti-GQ1b syndrome. All presented with MFS, one of them evolved to GBS pharyngeal-cervical-brachial variant and other to GBS with BBE. All had a previous history of diarrhea or upper respiratory tract infection. All had positive anti-GQ1b serum antibodies. Both brain magnetic resonance imaging and cerebrospinal fluid analysis were normal. Electrophysiology studies were compatible with a demyelinating disease. Two patients needed airway protection with an orotracheal tube and developed dysautonomia. All four patients were treated with immunomodulation. On the sixth month follow-up, patients had only minimal alterations in the neurological examination.

Palavras-Chave: Encephalitis; Gangliosides; Guillain Barré syndrome; Miller Fisher syndrome; Ophthalmoplegia

Imprenta: Revista Me?dica de Chile, v. 141, n. 9, p. 1211-1215, 2013

Identificador do objeto digital: 10.4067/S0034-98872013000900016

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2013

INDICADORES

ACESSO