Autor(es): Comont T,Bonnet D,Sigur N,Gerdelat A,Legrand-Abravanel F,Kamar N,Alric L

Resumo: Hepatitis E virus (HEV) infection is now recognized to be an emerging autochthonous disease in several countries. There have been several reports of neurological manifestations associated with HEV infections. Immunocompromised patients seem to be particularly vulnerable. We report a 73-year-old man who presented with an acute polyradiculopathy and an acute hepatitis. HEV RNA was positive in serum and cerebrospinal fluid. Serum antiganglioside antibodies were also detected. Liver function tests returned to normal rapidly and HEV RNA was undetectable 4 weeks after initial testing. The neurological features improved gradually with the use of intravenous immunoglobulins. We report a case of Guillain-Barré syndrome related to acute hepatitis E in an immunocompetent patient. The outcome was favorable after intravenous immunoglobulins administration. HEV screening should be systematic in patients who present with an acute polyradiculopathy and abnormal liver function tests.

Palavras-Chave: Anticorps Antigangliosides; Antiganglioside Antibodies; Guillain-Barré Syndrome, Hepatitis, Hepatitis E Virus, Hépatite, Immunoglobulines Intraveineuses, Intravenous Immunoglobulin, Polyradiculonévrite, Polyradiculopathy, Syndrome de Guillain-Barré, Virus de L'hépatite E

Imprenta: La Revue De Me?decine Interne / Fonde?e ... Par La Socie?te? Nationale Francaise de Me?decine Interne, v. 35, n. 5, p. 333-336, 2014

Identificador do objeto digital: 10.1016/j.revmed.2013.05.005

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - RNA ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2014

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