Autor(es): Müller M,Eckardt V,Schrank B,Graap H

Resumo: A 47-year-old patient with a history of Guillain-Barré syndrome three years prior to evaluation and a severe persisting sensory neuronopathy, complained of dysphagia especially for solid food. He also had severe, intermittent retrosternal pain. Radiological and manometric studies showed the typical features of achalasia. Treatment with botulinum toxin injection improved the dysphagia but not the retrosternal pain. An autoimmune response triggered by an infection is discussed as one possible cause of ganglion cell degeneration within the myenteric plexus in patients with achalasia. Such a hypothesis is supported by our observation showing the simultaneous occurrence of achalasia, sensory neuronopathy, and Guillain-Barré syndrome.

Palavras-Chave: Achalasia; Dysphagia; Guillain-Barré syndrome; Sensory neuronopathy; Autoantibodies; Botox injection

Imprenta: Zeitschrift fu?r Gastroenterologie, v. 47, n. 11, p. 1149-1152, 2009

Identificador do objeto digital: 10.1055/s-0028-1109121

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2009

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