Toxic effects on and structure-toxicity relationships of phenylpropanoids, terpenes, and related compounds in Aedes aegypti larvae
Autor(es): Santos Sandra R L,Silva Viviane B,Melo Manuela A,Barbosa Juliana D F,Santos Roseli L C,de Sousa Damião P,Cavalcanti Sócrates C H
Resumo: In the search for toxic compounds against Aedes aegypti L. (Diptera: Culicidae) larvae, a collection of commercially available aromatic and aliphatic diversely substituted compounds were selected and evaluated. p-Cymene exhibited the highest larvicidal potency LC?? = 51 ppm, whereas 1,8-cineole exhibited the lowest activity value LC?? = 1419 ppm. To aid future work on the search for larvicidal compounds, the structure-toxicity relationships of this collection have been evaluated. The presence of lipophilic groups results in an overall increase in potency. In general, the presence of hydroxyl groups resulted in less potent compounds. However, methylation of such hydroxyls led to an overall increase in potency. The most potent compounds showed comparably good larvicidal activity in A. aegypti larvae as other terpenes, which we assume to be the result of the increased lipophilicity
Imprenta: Vector Borne and Zoonotic Diseases, v. 10, n. 10, p. 1049-1054, 2010
Identificador do objeto digital: 10.1089/vbz.2009.0158
Descritores: Aedes aegypti - Public health
Data de publicação: 2010
