Tracking the re-emergence of epidemic chikungunya virus in Indonesia
Autor(es): Laras Kanti,Sukri Nono C,Larasati Ria P,Bangs Michael J,Kosim Rizal,Djauzi ,Wandra Tony,Master John,Kosasih Herman,Hartati Sri,Beckett Charmagne,Sedyaningsih Endang R,Beecham H James,Corwin Andrew L
Resumo: Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 +/- 18 years in Bogor and 33 +/- 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.
Palavras-Chave: Chikungunya virus; Epidemic; Indonesia
Imprenta: Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 99, n. 2, p. 128-141, 2005
Identificador do objeto digital: 10.1016/j.trstmh.2004.03.013
Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - RNA ; Aedes aegypti - Antibodies ; Aedes aegypti - Viral infections ; Aedes aegypti - RT-PCR ; Aedes aegypti - virus ; Aedes aegypti - Epidemic ; Aedes aegypti - Epidemiology ; Aedes aegypti - Immunology ; Aedes aegypti - Public health
Data de publicação: 2005
