Serological investigations of flavivirus prevalence in Khammouane Province, Lao People's Democratic Republic, 2007-2008
Autor(es): Hiscox Alexandra,Winter Christian H,Vongphrachanh Phengta,Sisouk Thongchanh,Somoulay Virasack,Phompida Samlane,Kaul Surinder,Sananikhom Pany,Nguyen Thi Yen,Paul Richard E,Brey Paul,Bryant Juliet E
Resumo: A large-scale cross-sectional seroprevalence study of dengue (DEN) and Japanese encephalitis (JE) was conducted in Khammouane province, Lao PDR, as part of the initial baseline health impact assessment of the Nam Theun 2 hydroelectric dam construction project. Health surveys were performed between May 2007 and February 2008 with serum samples collected from healthy individuals involved in the resettlement program of 16 villages (total surveyed population 4,369). Hemagglutination inhibition assay using flavivirus antigens (DENV1, DENV3, and JEV) performed on 1,708 plasma specimens revealed 30.4% (519) cross-reactive positives, and 10% (172) and 1.3% (22) positives to JEV or DENV, respectively. Entomological surveys conducted during the rainy season of 2008 indicated the presence of competent flavivirus vectors (Culex vishnui group and Aedes albopictus), although Aedes aegypti was not found. Continued surveillance and investigation is warranted to assess the clinical disease burden of flaviviruses in this area that is undergoing rapid ecological and demographic change.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 83, n. 5, p. 1166-1169, 2010
Identificador do objeto digital: 10.4269/ajtmh.2010.09-0480
Descritores: Aedes aegypti - Flaviviridae ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - Antibodies ; Aedes aegypti - Serology ; Aedes aegypti - Viral infections ; Aedes aegypti - Serological diagnosis ; Aedes aegypti - Serology ; Aedes aegypti - virus ; Aedes aegypti - Dengue ; Aedes aegypti - Epidemiology ; Aedes aegypti - Immunology ; Aedes aegypti - Public health
Data de publicação: 2010
