Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy
Autor(es): Karppinen A,Brummer-Korvenkontio H,Reunala T,Izquierdo I
Resumo: People frequently experience wealing and delayed papules from mosquito bites. Wealing is mediated by antisaliva IgE antibodies and histamine. Rupatadine is a new antihistamine effective in allergic rhinitis and urticaria, but the effect on mosquito-bite allergy is not known. To determine the effectiveness of rupatadine in inmediate mosquito-bite allergy-confirmed adult patients. A double-blind, placebo-controlled, cross-over study was performed with rupatadine 10 mg and matched placebo in 30 mosquito-bite-sensitive adults. The mean age was 37 years and the subjects had suffered from harmful mosquito bites for a mean of 15 years. Either rupatadine or placebo was taken at 08:00 am for 4 days, followed by a 5 day wash out period and then alternative treatment was given for 4 days. On day 3, in both drug periods the subjects received two Aedes aegypti mosquito-bites on the forearm. The size of lesions and intensity of pruritus [visual analogue scale (VAS)] were measured after 15 min bite reaction. Twenty-six subjects were analysed for efficacy. The size of the 15 min bite reaction under placebo was of 106 mm2 and under rupatadine, of 55 mm2. This is a significant decrease (48%; P=0.0003). The accompanying pruritus decreased from 60 (VAS; median) under placebo to 47.5 under rupatadine, which also is a significant (P=0.019) difference. There was no significant (P=0.263) difference in adverse events under rupatadine and placebo. The present placebo-controlled study in mosquito-bite-sensitive adults shows that rupatadine 10 mg prophylactically given is an effective treatment for the mosquito-bite wealing and skin pruritus.
Imprenta: Journal of the European Academy of Dermatology and Venereology : JEADV, v. 26, n. 7, p. 919-922, 2012
Identificador do objeto digital: 10.1111/j.1468-3083.2012.04543.x
Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Antibodies ; Aedes aegypti - Immunology ; Aedes aegypti - Public health
Data de publicação: 2012
