Topically applied AaeIAP1 double-stranded RNA kills female adults of Aedes aegypti
Autor(es): Pridgeon Julia W,Zhao Liming,Becnel James J,Strickman Daniel A,Clark Gary G,Linthicum Kenneth J
Resumo: Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to develop new insecticides to control mosquitoes, an inhibitor of apoptosis protein 1 gene in Aedes aegypti (AaeIAP1) was targeted for the development of molecular pesticides. Herein, for the first time, we report that topically applied AaeIAP1 double-stranded RNA products are able to kill female adults of Ae. aegypti. Our results indicate that critical pathways or genes could be targeted to develop molecular pesticides for the control of medically important diseases vectors.
Palavras-Chave: Aedes aegypti; RNA interference; Double-stranded RNA; Inhibitor of apoptosis; Pesticide
Imprenta: Journal of Medical Entomology, v. 45, n. 3, p. 414-420, 2008
Identificador do objeto digital: 10.1093/jmedent/45.3.414
Descritores: Aedes aegypti - Molecular Structure ; Aedes aegypti - RNA ; Aedes aegypti - Molecular methods ; Aedes aegypti - Dengue ; Aedes aegypti - Public health
Data de publicação: 2008
