Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera: Culicidae)
Autor(es): Mori Akio,Chadee Dave D,Graham Douglas H,Severson David W
Resumo: We have initiated efforts to determine the molecular basis for the M(D) meiotic drive system in the mosquito, Aedes aegypti. The effect of the M(D) gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder m(s) allele. The M(D) system has potential as a mechanism for driving trangenes for pathogen resistance into natural Ae. aegypti populations. Because all previously existing laboratory strains carrying the M(D) gene have been lost, we have selected for a new strain, T37, that carries a strong driver. Matings between T37 males and drive-susceptible m(s) females result in progeny with highly biased sex ratios, wherein only approximately 14.7% females are produced. We discuss the potential for identifying M(D) candidate genes based on comparisons with the well-described Drosophila melanogaster segregation distorter (SD) meiotic drive system and considerations for release of transgenic Ae. aegypti into natural populations where M(D) and insensitive m3 alleles are likely segregating.
Palavras-Chave: Sex ratio; Population replacement; Transgenic insects; Genetic control; Selection
Imprenta: Journal of Medical Entomology, v. 41, n. 6, p. 1027-1033, 2004
Identificador do objeto digital: 10.1603/0022-2585-41.6.1027
Descritores: Aedes aegypti - Genome ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Public health
Data de publicação: 2004
