Virus evolution and transmission in an ever more connected world
Autor(es): Pybus Oliver G, Tatem Andrew J, Lemey Philippe
Resumo: The frequency - global impact of infectious disease outbreaks, particularly those caused by emerging viruses, demonstrate the need for a better underst-ing of how spatial ecology - pathogen evolution jointly shape epidemic dynamics. Advances in computational techniques - the increasing availability of genetic - geospatial data are helping to address this problem, particularly when both information sources are combined. Here, we review research at the intersection of evolutionary biology, human geography - epidemiology that is working towards an integrated view of spatial incidence, host mobility - viral genetic diversity. We first discuss how empirical studies have combined viral spatial - genetic data, focusing particularly on the contribution of evolutionary analyses to epidemiology - disease control. Second, we explore the interplay between virus evolution - global dispersal in more depth for two pathogens: human influenza A virus - chikungunya virus. We discuss the opportunities for future research arising from new analyses of human transportation - trade networks, as well as the associated challenges in accessing - sharing relevant spatial - genetic data.
Palavras-Chave: Epidemiology; Evolution; Geography; Phylogenetics; Transmission; Virus
Imprenta: Proceedings. Biological Sciences / The Royal Society, v. 282, n. 1821, 2015
Identificador do objeto digital: 10.1098/rspb.2014.2878
Descritores: Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology
Data de publicação: 2015
