Viremia in north american mammals and birds after experimental infection with Chikungunya viruses
Autor(es): Bosco-Lauth Angela M, Nemeth Nicole M, Kohler Dennis J, Bowen Richard A
Resumo: Chikungunya virus (CHIKV) is an arthropod-borne virus, which is known to cause severe disease only in humans. To investigate its potential zoonotic host range - evaluate reservoir competence among these hosts, experimental infections were performed on individuals from nine avian - 12 mammalian species representing both domestic - wild animals common to North America. Hamsters - inbred mice have previously been shown to develop viremia after inoculation with CHIKV - were used as positive controls for infection. Aside from big brown bats (Eptesicus fuscus), none of the mammals or birds developed detectable viremia or overt clinical disease. However, most mammals - a smaller proportion of birds developed neutralizing antibody responses to CHIKV. On the basis of these results, it seems unlikely that CHIKV poses a significant health threat to most domestic animals or wildlife - that the species examined do not likely contribute to natural transmission cycles. Additional studies should further evaluate bats - wild rodents as potential reservoir hosts for CHIKV transmission during human epidemics.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 94, n. 3, p. 504-506, 2016
Identificador do objeto digital: 10.4269/ajtmh.15-0696
Descritores: Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemic
Data de publicação: 2016
