Autor(es): Brandler Samantha, Tangy Frederic

Resumo: West Nile encephalitis emerged in 1999 in the United States, then rapidly spread through the North American continent causing severe disease in human - horses. Since then, outbreaks appeared in Europe, - in 2012, the United States experienced a new severe outbreak reporting a total of 5,387 cases of West Nile virus (WNV) disease in humans, including 243 deaths. So far, no human vaccine is available to control new WNV outbreaks - to avoid worldwide spreading. In this review, we discuss the state-of-the-art of West Nile vaccine development - the potential of a novel safe - effective approach based on recombinant live attenuated measles virus (MV) vaccine. MV vaccine is a live attenuated negative-str-ed RNA virus proven as one of the safest, most stable - effective human vaccines. We previously described a vector derived from the Schwarz MV vaccine strain that stably expresses antigens from emerging arboviruses, such as dengue, West Nile or chikungunya viruses, - is strongly immunogenic in animal models, even in the presence of MV pre-existing immunity. A single administration of a recombinant MV vaccine expressing the secreted form of WNV envelope glycoprotein elicited protective immunity in mice - non-human primates as early as two weeks after immunization, indicating its potential as a human vaccine.

Palavras-Chave: West Nile vaccine; West Nile virus; Measles vaccine; Recombinant live attenuated vaccine; Flavivirus

Imprenta: Viruses, v. 5, n. 10, p. 2384-2409, 2013

Identificador do objeto digital: 10.3390/v5102384

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2013

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