Use of human monoclonal antibodies to treat Chikungunya virus infection
Autor(es): Fric Jan, Bertin-Maghit Sébastien, Wang Cheng-I, Nardin Alessandra, Warter Lucile
Resumo: Chikungunya virus (CHIKV) is an alphavirus prevalent in tropical regions. It causes an acute febrile disease that, in elderly individuals - newborns, is often associated with severe complications. We previously reported the isolation - characterization of 2 human monoclonal antibodies neutralizing CHIKV in vitro: 5F10 - 8B10. Here, we tested their efficacy in vivo as prophylactic - therapeutic treatments of CHIKV infection in AGR129 mice. In both settings, 5F10 - 8B10 were able to significantly delay CHIKV-driven lethality. Our results support the development of prophylactic - therapeutic treatments for CHIKV infection, using a combination of 5F10 - 8B10.
Imprenta: The Journal of Infectious Diseases, v. 207, n. 2, p. 319-322, 2013
Identificador do objeto digital: 10.1093/infdis/jis674
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology
Data de publicação: 2013
