Autor(es)Hoke Charles H, Pace-Templeton Judy, Pittman Phillip, Malinoski Frank J, Gibbs Paul, Ulderich Tracy, Mathers Michelle, Fogtman Beverly, Glass Pamela, Vaughn David W

ResumoChikungunya virus, transmitted by mosquitoes to man, causes an acute illness characterized by fever, rash - striking joint symptoms. US Military investigators developed, manufactured at The Salk Institute-Government Services Division (TSI-GSD), - tested the live, attenuated Chikungunya Vaccine TSI-GSD-218. The manufacturing facility stopped production in 1994. The Chikungunya Vaccine TSI-GSD-218 development effort was terminated in 1998, - materials were archived. In 2005, an alarming outbreak of chikungunya disease began in Africa - spread to isl-s in the Indian Ocean - throughout much of Asia. Abrupt epidemics with high attack rates - serious, even fatal, complications were reported, - travelers carried the virus to Europe - the Americas. In response to urgent requests, the US Military offered assistance by providing non-exclusive access to the previously stored vaccine production seed materials, bulk vaccine, regulatory documentation, - reports of previous clinical trials. Five companies requested technology transfers. This experience provides lessons about epidemiological unpredictability, preparedness, vaccine manufacturing, the potential global importance of vaccine seed materials - the advisability of a global strategic plan. Consideration should be given to banking of vaccine production seeds, cell substrates, - manufacturing instructions. In view of the manufacturability, attenuation, - immunogenicity of Chikungunya Vaccine TSI-GSD-218, authorities may wish to consider this product as a possible c-idate itself, as a comparator vaccine to improve upon, as a seed for inactivated vaccine, or as a source of virus or antigen for neutralization assays or immunoassays.

Palavras-ChaveChikungunya; Vaccine; Manufacturing; US Military; Pandemic

ImprentaVaccine, v. 30, n. 47, p. 6713-6720, 2012

DescritoresChikungunya virus - Cell ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Public health

Data de Publicação:2012