Autor(es): Sam I-Ching, Kümmerer Beate M, Chan Yoke-Fun, Roques Pierre, Drosten Christian, AbuBakar Sazaly

Resumo: Chikungunya virus (CHIKV) is an Aedes-borne alphavirus, historically found in Africa - Asia, where it caused sporadic outbreaks. In 2004, CHIKV reemerged in East Africa - spread globally to cause epidemics, including, for the first time, autochthonous transmission in Europe, the Middle East, - Oceania. The epidemic strains were of the East/Central/South African genotype. Strains of the Asian genotype of CHIKV continued to cause outbreaks in Asia - spread to Oceania -, in 2013, to the Americas. Acute disease, mainly comprising fever, rash, - arthralgia, was previously regarded as self-limiting; however, there is growing evidence of severe but rare manifestations, such as neurological disease. Furthermore, CHIKV appears to cause a significant burden of long-term morbidity due to persistent arthralgia. Diagnostic assays have advanced greatly in recent years, although there remains a need for simple, accurate, - affordable tests for the developing countries where CHIKV is most prevalent. This review focuses on recent important work on the epidemiology, clinical disease - diagnostics of CHIKV.

Palavras-Chave: Arthralgia; Chikungunya; Epidemiology; Genotype; Molecular diagnostics; Serologic tests; Signs and symptoms

Imprenta: Vector Borne and Zoonotic Diseases, v. 15, n. 4, p. 223-230, 2015

Identificador do objeto digital: 10.1089/vbz.2014.1680

Descritores: Chikungunya virus - Serology ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology

Data de publicação: 2015

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