Unconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicity
Autor(es): Petitdemange Caroline, Becquart Pierre, Wauquier Nadia, Béziat Vivien, Debré Patrice, Leroy Eric M, Vieillard Vincent
Resumo: Chikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes a syndrome characterized by high fever, polyarthritis, - in some cases lethal encephalitis. Growing evidence indicates that the innate immune response plays a role in controlling CHIKV infection. We show here that CHIKV induces major but transient modifications in NK-cell phenotype - function soon after the onset of acute infection. We report a transient clonal expansion of NK cells that coexpress CD94/NKG2C - inhibitory receptors for HLA-C1 alleles - are correlated with the viral load. Functional tests reveal cytolytic capacity driven by NK cells in the absence of exogenous signals - severely impaired IFN-? production. Collectively these data provide insight into the role of this unique subset of NK cells in controlling CHIKV infection by subset-specific expansion in response to acute infection, followed by a contraction phase after viral clearance.
Imprenta: PLoS Pathogens, v. 7, n. 9, p. e1002268, 2011
Identificador do objeto digital: 10.1371/journal.ppat.1002268
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Immune response ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology
Data de publicação: 2011
