Unconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicity
Autor(es)Petitdemange Caroline, Becquart Pierre, Wauquier Nadia, Béziat Vivien, Debré Patrice, Leroy Eric M, Vieillard Vincent
ResumoChikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes a syndrome characterized by high fever, polyarthritis, - in some cases lethal encephalitis. Growing evidence indicates that the innate immune response plays a role in controlling CHIKV infection. We show here that CHIKV induces major but transient modifications in NK-cell phenotype - function soon after the onset of acute infection. We report a transient clonal expansion of NK cells that coexpress CD94/NKG2C - inhibitory receptors for HLA-C1 alleles - are correlated with the viral load. Functional tests reveal cytolytic capacity driven by NK cells in the absence of exogenous signals - severely impaired IFN-? production. Collectively these data provide insight into the role of this unique subset of NK cells in controlling CHIKV infection by subset-specific expansion in response to acute infection, followed by a contraction phase after viral clearance.
ImprentaPLoS Pathogens, v. 7, n. 9, p. e1002268, 2011
Identificador do Objeto Digital10.1371/journal.ppat.1002268
DescritoresChikungunya virus - Cell ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Immune response ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology
Data de Publicação:2011
