Travel-associated chikungunya cases in South Korea during 2009-2010
Autor(es): Cha Go Woon, Cho Jung Eun, Lee Eun Ju, Ju Young Ran, Han Myung Guk, Park Chan, Jeong Young Eui
Resumo: Chikungunya (CHIK) has been classified as a communicable disease group IV in South Korea since late 2010. Based on this, we investigated the extent of imported cases of CHIK in dengue-suspected individuals returning from dengue-endemic regions. A total of 486 dengue-suspected serum samples were screened for CHIK by enzyme-linked immunosorbent assay (ELISA) - reverse transcription-polymerase chain reaction (RT-PCR) analysis. Further RT-PCR-positive samples were used for the viral culture, - CHIK was subsequently confirmed by sequence analysis of the culture samples. Five out of 107 dengue-positive samples were found to be positive for CHIK - 15 out of 379 dengue-negative samples were found to be positive for CHIK by immunoglobulin M ELISA. Further, a CHIK virus was isolated from one of the two RT-PCR-positive sera by cell culture - confirmed by sequence analysis. The present study documents the first evidence of travel-associated CHIK infection in South Korea. Considering the intense international traffic between countries, our finding emphasizes the urgent need for active patient - vector surveillance for timely response to reduce the introduction of CHIK in Korea.
Palavras-Chave: Chikungunya; Dengue; Enzyme-linked immunosorbent assay; Reverse transcription-polymerase chain reaction
Imprenta: Osong Public Health and Research Perspectives, v. 4, n. 3, p. 170-175, 2013
Identificador do objeto digital: 10.1016/j.phrp.2013.04.008
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cell ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue ; Chikungunya virus - Public health
Data de publicação: 2013
