Autor(es): Kariuki Njenga M, Nderitu L, Ledermann J P, Ndirangu A, Logue C H, Kelly C H L, Sang R, Sergon K, Breiman R, Powers A M

Resumo: The largest documented outbreak of Chikungunya virus (CHIKV) disease occurred in the Indian Ocean isl-s - India during 2004-2007. The magnitude of this outbreak led to speculation that a new variant of the virus had emerged that was either more virulent or more easily transmitted by mosquito vectors. To study this assertion, it is important to know the origin of the virus - how the particular strain circulating during the outbreak is related to other known strains. This study genetically characterized isolates of CHIKV obtained from Mombasa - Lamu Isl-, Kenya, during 2004, as well as strains from the 2005 outbreak recorded in Comoros. The results of these analyses demonstrated that the virus responsible for the epidemic that spread through the Indian Ocean originated in coastal Kenya during 2004 - that the closest known ancestors are members of the Central/East African clade. Genetic elements that may be responsible for the scope of the outbreak were also identified.

Imprenta: The Journal of General Virology, v. 89, Pt 11, p. 2754-2760, 2008

Identificador do objeto digital: 10.1099/vir.0.2008/005413-0

Descritores: Chikungunya virus - Cell ; Chikungunya virus - DNA ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology

Data de publicação: 2008

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