Autor(es)Ahola Tero, Courderc Therese, Ng Lisa F P, Hallengärd David, Powers Ann, Lecuit Marc, Esteban Mariano, Merits Andres, Roques Pierre, Liljeström Peter

ResumoCurrently, there are no licensed vaccines or therapies available against chikungunya virus (CHIKV), - these were subjects discussed during a CHIKV meeting recently organized in Langkawi, Malaysia. In this review, we chart the approaches taken in both areas. Because of a sharp increase in new data in these fields, the present paper is complementary to previous reviews by Weaver et al. in 2012 - Kaur - Chu in 2013 . The most promising antivirals so far discovered are reviewed, with a special focus on the virus-encoded replication proteins as potential targets. Within the vaccines in development, our review emphasizes the various strategies in parallel development that are unique in the vaccine field against a single disease.

Palavras-ChaveAntibodies; Antiviral; Attenuated virus; Chikungunya; DNA chimeric viruses; Polymerase; Protease; Vaccine; Virus-like particles

ImprentaVector Borne and Zoonotic Diseases, v. 15, n. 4, p. 250-257, 2015

DescritoresChikungunya virus - DNA ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine

Data de Publicação:2015