Autor(es): Reid Colleen R, Airo Adriana M, Hobman Tom C

Resumo: Positive-str- RNA (+RNA) viruses are an important group of human - animal pathogens that have significant global health - economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus - enteroviruses of the Picornaviridae family.Unfortunately, prophylactic - therapeutic treatments against these pathogens are limited. +RNA viruses have limited coding capacity - thus rely extensively on host factors for successful infection - propagation. A common feature among these viruses is their ability to dramatically modify cellular membranes to serve as platforms for genome replication - assembly of new virions. These viral replication complexes (VRCs) serve two main functions: To increase replication efficiency by concentrating critical factors - to protect the viral genome from host anti-viral systems. This review summarizes current knowledge of critical host factors recruited to or demonstrated to be involved in the biogenesis - stabilization of +RNA virus VRCs.

Palavras-Chave: RNA viruses; Host factors; Membranes; Replication complexes

Imprenta: Viruses, v. 7, n. 8, p. 4385-4413, 2015

Identificador do objeto digital: 10.3390/v7082825

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Genome ; Chikungunya virus - RNA ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue ; Chikungunya virus - Immunology

Data de publicação: 2015

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