Autor(es): Johnson Karyn N

Resumo: Mosquito-borne viruses such as dengue, West Nile - chikungunya viruses cause significant morbidity - mortality in human populations. Since current methods are not sufficient to control disease occurrence, novel methods to control transmission of arboviruses would be beneficial. Recent studies have shown that virus infection - transmission in insects can be impeded by co-infection with the bacterium Wolbachia pipientis. Wolbachia is a maternally inherited endosymbiont that is commonly found in insects, including a number of mosquito vector species. In Drosophila, Wolbachia mediates antiviral protection against a broad range of RNA viruses. This discovery pointed to a potential strategy to interfere with mosquito transmission of arboviruses by artificially infecting mosquitoes with Wolbachia. This review outlines research on the prevalence of Wolbachia in mosquito vector species - the impact of antiviral effects in both naturally - artificially Wolbachia-infected mosquitoes.

Palavras-Chave: Drosophila; Wolbachia; Antiviral effects; Antiviral protection; Arbovirus; Insect virus; Mosquito; Symbiosis

Imprenta: Viruses, v. 7, n. 11, p. 5705-5717, 2015

Identificador do objeto digital: 10.3390/v7112903

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - RNA ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue

Data de publicação: 2015