Autor(es): Rodríguez-Barraquer Isabel, Solomon Sunil S, Kuganantham Periaswamy, Srikrishnan Aylur Kailasom, Vasudevan Canjeevaram K, Iqbal Syed H, Balakrishnan Pachamuthu, Solomon Suniti, Mehta Shruti H, Cummings Derek A T

Resumo: Dengue - chikungunya are rapidly exp-ing viruses transmitted by mosquitoes of the genus Aedes. Few epidemiological studies have examined the extent of transmission of these infections in South India despite an increase in the number of reported cases, - a high suitability for transmission. We conducted a household-based seroprevalence survey among 1010 individuals aged 5-40 years living in fifty r-omly selected spatial locations in Chennai, Tamil Nadu. Participants were asked to provide a venous blood sample - to complete a brief questionnaire with basic demographic - daily activity information. Previous exposure to dengue - chikungunya was determined using IgG indirect ELISA (Panbio) - IgG ELISA (Novatec), respectively. We used this data to estimate key transmission parameters (force of infection - basic reproductive number) - to explore factors associated with seropositivity. While only 1% of participants reported history of dengue - 20% of chikungunya, we found that 93% (95%CI 89-95%) of participants were seropositive to dengue virus, - 44% (95%CI 37-50%) to chikungunya. Age-specific seroprevalence was consistent with long-tem, endemic circulation of dengue - suggestive of epidemic chikungunya transmission. Seropositivity to dengue - chikungunya were significantly correlated, even after adjusting for individual - household factors. We estimate that 23% of the susceptible population gets infected by dengue each year, corresponding to approximately 228,000 infections. This transmission intensity is significantly higher than that estimated in known hyperendemic settings in Southeast Asia - the Americas. These results provide unprecedented insight into the very high transmission potential of dengue - chikungunya in Chennai - underscore the need for enhanced surveillance - control methods.

Imprenta: PLoS Neglected Tropical Diseases, v. 9, n. 7, p. e0003906, 2015

Identificador do objeto digital: 10.1371/journal.pntd.0003906

Descritores: Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic

Data de publicação: 2015

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