The green tea catechin, epigallocatechin gallate inhibits Chikungunya virus infection
Autor(es): Weber Christopher, Sliva Katja, von Rhein Christine, Kümmerer Beate M, Schnierle Barbara S
Resumo: Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes chikungunya fever - has infected millions of people mainly in developing countries. The associated disease is characterized by rash, high fever - severe arthritis that can persist for years. CHIKV has adapted to Aedes albopictus, which also inhabits temperate regions, including Europe - the United States of America - might cause new, large outbreaks there. No treatment or licensed CHIKV vaccine exists. Epigallocatechin-3-gallate (EGCG), the major component of green tea, has, among other beneficial properties, antiviral activities. Therefore, we examined if EGCG has antiviral activity against CHIKV. EGCG inhibited CHIKV infection in vitro, blocked entry of CHIKV Env-pseudotyped lentiviral vectors - inhibited CHIKV attachment to target cells. Thus EGCG might be used as a lead structure to develop more effective antiviral drugs.
Palavras-Chave: Chikungunya virus; EGCG; Green tea
Imprenta: Antiviral Research, v. 113, p. 1-3, 2015
Identificador do objeto digital: 10.1016/j.antiviral.2014.11.001
Descritores: Chikungunya virus - Cell ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever
Data de publicação: 2015
