The distribution and prevalence of group A arbovirus neutralizing antibodies among human populations in Southeast Asia and the Pacific islands
Autor(es): Tesh R B, Gajdusek D C, Garruto R M, Cross J H, Rosen L
Resumo: Plaque reduction neutralization tests, using five group A arboviruses (chikungunya, Ross River, Getah, Bebaru - Sindbis), were done on sera from human populations in 44 Southeast Asia - Pacific isl- localities. Specificity of the plaque neutralization test was determined by examining convalescent sera from patients with known alphavirus infections. Chikungunya-specific neutralizing antibodies were demonstrated in sera of persons living in South Vietnam, Northern Malaysia, Indonesia (Kalimantan - Sulawesi), as well as Luzon, Marinduque, Cebu - Mindanao isl-s in the Philippines. Evidence of Ross River virus infection was found among populations living in West New Guinea - Papua New Guinea mainl-, the Bismark Archipelago, Rossel Isl- - the Solomon Isl-s. There appeared to be no geographic overlap in the distribution of chikungunya - Ross River viruses, with the separation in their distribution corresponding with Weber's line in the Pacific. Sindbis neutralizing antibodies were found in 7 of 21 populations sampled, but in general the prevalence of infection was low. Four sera, from Vietnam, Malaysia - Mindanao gave monospecific reactions with Getah virus. No evidence of specific Bebaru virus infection was detected. The epidemiology of these five alphaviruses in Southeast Asia - the Pacific isl-s is discussed.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 24, n. 4, p. 664-675, 1975
Identificador do objeto digital: 10.4269/ajtmh.1975.24.664
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 1975
