The confirmation of three repeated sequence elements in the 3' untranslated region of Chikungunya virus
Autor(es): Zhang Yu, Si Bing-Yin, Kang Xiao-Ping, Hu Yi, Li Jing, Wu Xiao-Yan, Li Yu-Chang, Yang Yin-Hui, Zhu Qing-Yu
Resumo: In this study, the complete genomic nucleotide sequence of Chikungunya virus (CHIKV) strain S27 African prototype was determined - three 21 nucleotides repeated sequence elements (RSEs) at positions 11398-11418, 11533-11553, - 11620-11640 in the 3' untranslated region (3'UTR) were confirmed. In addition, the 3'UTRs of all CHIKV strains deposited in GenBank were analyzed. The results displayed that the majority of the CHIKV strains consisted of the three 21 nucleotides RSEs in the 3'UTRs, - the third RSE was the most conservative. The conservation of the three RSEs of 21 nucleotides within the 3'UTR of CHIKV genome may play an important role on the virus replication cycle.
Palavras-Chave: Chikungunya virus; Repeated sequence element; Untranslated region
Imprenta: Virus Genes, v. 46, n. 1, p. 165-166, 2013
Identificador do objeto digital: 10.1007/s11262-012-0835-5
Descritores: Chikungunya virus - DNA ; Chikungunya virus - Genome ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2013
