Autor(es): Tang Bor Luen

Resumo: Chikungunya virus (CHIKV) infection causes a disease which appears to affect multiple cell types - tissues. The acute phase is manifested by a non-fatal febrile illness, polyarthralgia - maculopapular rashes in adults, but with recurrent arthralgia that may linger for months during convalescence. The issue of cellular - tissue tropism of CHIKV has elicited interest primarily because of this lingering incapacitating chronic joint pain, as well as clear encephalopathy in severe cases among neonates during the re-emergence of the virus in recent epidemics. The principle cell types productively infected by CHIKV are skin fibroblasts, epithelial cells - lymphoid tissues. There is controversy as to whether CHIKV productively infects haematopoietic cells - neurones/glia. CHIKV infection triggers rapid - robust innate immune responses which quickly clears the acute phase infection. However, significant acute as well as chronic infection of less obvious cell types, such as monocytes, neurones/glia or even CNS neural progenitors may conceivably occur. There is therefore a need to ascertain the full range potential of CHIKV tropism, fully underst- the cellular responses triggered during the acute the convalescent phases, - explore possible cell types that might be the source of chronic problems associated with CHIKV infection.

Imprenta: Cellular Microbiology, v. 14, n. 9, p. 1354-1363, 2012

Identificador do objeto digital: 10.1111/j.1462-5822.2012.01825.x

Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic

Data de publicação: 2012

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