The antiviral activities of ISG15
Autor(es): Morales David J, Lenschow Deborah J
Resumo: Post-translational protein modification is an important strategy for the regulation of the cell proteome independent of the need for new gene expression. Ubiquitin - ubiquitin-like modifiers mediate the regulation of protein levels, signaling pathways, vesicular trafficking, - many other cellular processes through their covalent conjugation to proteins. Interferon stimulated gene 15 (ISG15) is a ubiquitin-like modifier induced by type I interferon. In addition to conjugating to potentially hundreds of target proteins, ISG15 can be found in an unconjugated form both inside of the cell - released from interferon stimulated cells into the extracellular environment. Due to its robust expression after type I interferon stimulation - the broad panel of proteins that it targets, ISG15 has drawn much attention as a potential regulator of the immune response - has been shown to mediate protection in a number of different viral infection models. Here we will review the current state of the field of ISG15, the viruses against which ISG15 mediates protection, - the mechanisms by which ISG15 exerts antiviral activity.
Imprenta: Journal of Molecular Biology, v. 425, n. 24, p. 4995-5008, 2013
Identificador do objeto digital: 10.1016/j.jmb.2013.09.041
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - Proteome ; Chikungunya virus - RNA ; Chikungunya virus - Cytokines ; Chikungunya virus - Immune response ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology
Data de publicação: 2013
