Systems analysis of West Nile virus infection
Autor(es): Suthar Mehul S, Pulendran Bali
Resumo: Emerging - re-emerging mosquito-borne viruses continue to pose a significant threat to human health throughout the world. Over the past decade, West Nile virus (WNV), Dengue virus (DENV), - Chikungunya virus (CHIKV), have caused annual epidemics of virus-induced encephalitis, hemorrhagic fever\shock syndromes, - arthritis, respectively. Currently, no specific antiviral therapies or vaccines exist for use in humans to combat or prevent these viral infections. Thus, there is a pressing need to define the virus-host interactions that govern immunity - infection outcome. Recent technological breakthroughs in 'omics' resources - high-throughput based assays are beginning to accelerate antiviral drug discovery - improve on current strategies for vaccine design. In this review, we highlight studies with WNV - discuss how traditional - systems biological approaches are being used to rapidly identify novel host targets for therapeutic intervention - develop a deeper conceptual underst-ing of the host response to virus infection.
Imprenta: Current Opinion in Virology, v. 6, p. 70-75, 2014
Identificador do objeto digital: 10.1016/j.coviro.2014.04.010
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic
Data de publicação: 2014
