Systemic involvements and fatalities during Chikungunya epidemic in India, 2006
Autor(es): Tandale Babasaheb V, Sathe Padmakar S, Arankalle Vidya A, Wadia R S, Kulkarni Rahul, Shah Sudhir V, Shah Sanjeev K, Sheth Jay K, Sudeep A B, Tripathy Anuradha S, Mishra Akhilesh C
Resumo: In addition to classical manifestations of Chikungunya infection, severe infections requiring hospitalization were reported during outbreaks in India in 2006. To describe the systemic syndromes - risk groups of severe Chikungunya infections. We prospectively investigated suspected Chikungunya cases hospitalized in Ahmedabad, Gujarat during September-October 2006, - retrospectively investigated laboratory-confirmed Chikungunya cases hospitalized with neurologic syndromes in Pune, Maharashtra. Hospital records were reviewed for demographic, comorbidity, clinical - laboratory information. Sera -/or cerebrospinal fluid were screened by one or more methods, including virus-specific IgM antibodies, viral RNA - virus isolation. Among 90 laboratory-confirmed Chikungunya cases hospitalized in Ahmedabad, classical Chikungunya was noted in 25 cases - severe Chikungunya was noted in 65 cases, including non-neurologic (25) - neurologic (40) manifestations. Non-neurologic systemic syndromes in the 65 severe Chikungunya cases included renal (45), hepatic (23), respiratory (21), cardiac (10), - hematologic manifestations (8). Males (50) - those aged >or=60 years (50) were commonly affected with severe Chikungunya, - age >or=60 years represented a significant risk. Comorbidities were seen in 21 cases with multiple comorbidities in 7 cases. Among 18 deaths, 14 were males, 15 were aged >or=60 years - 5 had comorbidities. In Pune, 59 laboratory-confirmed Chikungunya cases with neurologic syndromes were investigated. Neurologic syndromes in 99 cases from Ahmedabad - Pune included encephalitis (57), encephalopathy (42), - myelopathy (14) or myeloneuropathy (12). Chikungunya infection can cause systemic complications - probably deaths, especially in elderly adults.
Palavras-Chave: Chikungunya virus; Encephalitis; Death; Elderly; Comorbidity
Imprenta: Journal of Clinical Virology, v. 46, n. 2, p. 145-159, 2009
Identificador do objeto digital: 10.1016/j.jcv.2009.06.027
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2009
