State of the art: What we know about infectious agents and myositis
Autor(es): Gan Lu, Miller Frederick W
Resumo: Increasing evidence suggests that the idiopathic inflammatory myopathies (IIMs) result from certain environmental exposures in genetically susceptible individuals. Investigations have demonstrated that a variety of infections not only cause infectious myopathies but also could be possible triggers for IIM. This review summarizes published studies on the possible roles of infections in inflammatory muscle disease. Many infectious agents have been linked to the development of IIMs via case reports, epidemiologic investigations, - animal models. Additional agents possibly involved in triggering the development of IIMs have been recently described, including Torque teno virus (TTV) - Borrelia burgdorferi. Novel animal models of myositis have been recently developed using Leishmania infantum or Chikungunya virus (CHIKV). New technologies to assess infectious agents include high-throughput methods for pathogen identification - novel approaches to identify gene expression of pathogens in tissues. Underst-ing the causes of IIMs remains limited in part due to the rarity - heterogeneity of these disorders. Although no definitive studies have yet linked infectious agents with IIMs, additional evidence is accumulating - novel technologies may allow improved underst-ing of the roles of infections in IIMs - for possible future therapeutic - preventive measures.
Palavras-Chave: Idiopathic inflammatory myopathy; Infection; Infectious myopathy; Pathogenesis
Imprenta: Current Opinion in Rheumatology, v. 23, n. 6, p. 585-594, 2011
Identificador do objeto digital: 10.1097/BOR.0b013e32834b5457
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology
Data de publicação: 2011
