Species-specific impact of the autophagy machinery on Chikungunya virus infection
Autor(es): Judith Delphine, Mostowy Serge, Bourai Mehdi, Gangneux Nicolas, Lelek Mickaël, Lucas-Hourani Marianne, Cayet Nadège, Jacob Yves, Prévost Marie-Christine, Pierre Philippe, Tangy Frédéric, Zimmer Christophe, Vidalain Pierre-Olivier, Couderc Thérèse, Lecuit Marc
Resumo: Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid - targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 - NDP52 in viral infection, - identify NDP52 as a cellular factor that accounts for CHIKV species specificity.
Palavras-Chave: Autophagy; Chikungunya virus; P62; NDP52; Species Specificity
Imprenta: EMBO Reports, v. 14, n. 6, p. 534-544, 2013
Identificador do objeto digital: 10.1038/embor.2013.51
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever
Data de publicação: 2013
