Severe bullous skin lesions associated with Chikungunya virus infection in small infants
Autor(es): Robin Stéphanie, Ramful Duksha, Zettor Julie, Benhamou Léon, Jaffar-B-jee Marie-Christine, Rivière Jean-Pierre, Marichy Jacques, Ezzedine Khaled, Alessandri Jean-Luc
Resumo: The aim of this study was to describe a pediatric case series of Chikungunya infection associated with extensive bullous skin lesions, a severe - unknown form of the disease, during the 2005-2006 outbreak in La Réunion Isl-. Retrospective descriptive hospital-based study in children presenting blisters > or = 10% of total body surface area with laboratory-confirmed Chikungunya infection. Eight boys - five girls with a mean age of 3.4 months were included. Blistering began after an average of 2 days after onset of fever - affected 21.5% (10% to 35%) of the total body surface area. Reverse transcription-polymerase chain reaction of blister fluid (n = 5) was positive with a mean viral load sometimes higher than in concurrent serum. Histopathologic examination (n = 10) showed intraepidermal blisters. Hospitalization - repeated dressing changes under general anesthesia were required. No death occurred. On follow-up, long term repigmentation was excellent with sometimes cosmetic sequelae. Chikungunya should be included in the differential diagnosis of febrile blistering dermatoses in small infants in epidemic areas.
Palavras-Chave: Chikungunya; Pediatric; Blisters; Arbovirus; Skin; Bullous dermatosis
Imprenta: European Journal of Pediatrics, v. 169, n. 1, p. 67-72, 2010
Identificador do objeto digital: 10.1007/s00431-009-0986-0
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2010
