Seroprevalence survey of Chikungunya virus in Bagan Panchor, Malaysia

Autor(es): Ayu Said Mas, Lai Li Rong, Chan Yoke Fun, Hatim Ahmad, Hairi Noran Naqiah, Ayob Asiah, Sam I-Ching


Resumo: In 2006, an outbreak of Chikungunya virus (CHIKV) of the Asian genotype affected over 200 people in Bagan Panchor village in Malaysia. One year later, a post-outbreak survey was performed to determine attack rate, asymptomatic rate, - post-infection sequelae. Findings were compared with recent CHIKV outbreaks of the Central/East African genotype. A total of 180 residents were interviewed for acute symptoms - post-infection physical quality of life - depressive symptoms. Sera from 72 residents were tested for CHIKV neutralizing antibodies. The estimated attack rate was 55.6%, - 17.5% of infected residents were asymptomatic. Arthralgia was reported up to 3 months after infection, but there were no reports of long-term functional dependence or depression. Symptomatic - seropositive residents were significantly more likely to live in the area with the most dense housing - commercial activities. CHIKV had a high attack rate - considerable clinical impact during the Bagan Panchor outbreak.


Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 83, n. 6, p. 1245-1248, 2010


Identificador do objeto digital: 10.4269/ajtmh.2010.10-0279


Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health


Data de publicação: 2010