Autor(es): Sergon Kibet, Yahaya Ali Ahmed, Brown Jennifer, Bedja Said A, Mlindasse Mohammed, Agata Naphtali, Allaranger Yokouide, Ball Mamadou D, Powers Ann M, Ofula Victor, Onyango Clayton, Konongoi Limbaso S, Sang Rosemary, Njenga M Kariuki, Breiman Robert F

Resumo: An outbreak of Chikungunya virus (CHIKV) illness associated with high fever combined with prolonged - severe arthralgias occurred on Gr-e Comore Isl- from January through May 2005; 5,202 cases were reported. A seroprevalence study was conducted to define the extent of transmission on the isl-. We conducted a cross-sectional survey using a multistage sampling technique. A total of 481 households were sampled. In each household, one resident was selected r-omly for interview - blood collection. We administered questionnaires - tested 331 sera for CHIKV-specific IgM - IgG antibodies by capture enzyme-linked immunosorbent assay. Infection with CHIKV infection (seropositivity) was defined as presence of IgG -/or IgM antibodies to CHIKV. A total of 331 (69%) of 481 survey participants consented to blood collection. Antibodies to CHIKV were detected in 63% of sera; IgM antibodies were found in 60% of specimens - IgG antibodies were detected in 27% of specimens. Extrapolation of the findings to the entire Gr-e Comore population suggested that nearly 215,000 people were infected with CHIKV during the outbreak. A total of 79% of the seropositive persons were hospitalized or stayed at home in bed for a mean of 6 days (range = 1-30 days); 52% missed work or school for a mean of 7 days (range = 1-40 days). The findings suggest that CHIKV was broadly transmitted during the outbreak with a high attack rate. Although not fatal during this outbreak, CHIKV infection caused significant morbidity - decreased economic productivity.

Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 76, n. 6, p. 1189-1193, 2007

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2007