Seroprevalence of antibodies against Chikungunya, Dengue, and Rift Valley fever viruses after febrile illness outbreak, Madagascar
Autor(es): Schwarz Norbert G, Girmann Mirko, Randriamampionona Njary, Bialonski Alexandra, Maus Deborah, Krefis Anne Caroline, Njarasoa Christine, Rajanalison Jeanne Fleury, Ramandrisoa Herly Daniel, Randriarison Maurice Lucien, May Jürgen, Schmidt-Chanasit Jonas, Rakotozandrindrainy Raphael
Resumo: In October 2009, two-3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), - Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% - 23%; IgM seroprevalence was 28% - 5%. IgG seroprevalence against DENV was 17% - 11%. No anti-DENV IgM was detected. At 4 locations, 450-1,300 m high, IgG seroprevalence against CHIKV was 0%-3%, suggesting CHIKV had not spread to higher inl--altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain - stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission.
Imprenta: Emerging Infectious Diseases, v. 18, n. 11, p. 1780-1786, 2012
Identificador do objeto digital: 10.3201/eid1811.111036
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2012
