Autor(es): Sissoko Daouda, Moendandze Amrat, Malvy Denis, Giry Claude, Ezzedine Khaled, Solet Jean Louis, Pierre Vincent

Resumo: Since 2006, Chikungunya virus (CHIKV) has re-emerged as an important pathogen of global concern. However, individual - household factors associated with the acquisition - the magnitude of clinically silent CHIKV infections remain poorly understood. In this present study, we aimed to investigate the seroprevalence, estimate the proportion of symptomatic illness - identify the risk factors for CHIKV infection in the primo-exposed population of Mayotte. METHODS/ PRINCIPAL FINDINGS: We conducted a household-based cross sectional serosurvey in Mayotte in November - December 2006 using complex multistage cluster sampling. To produce the results representative of the isl- population aged 2 years or older, sample data were adjusted with sample weights. Explanatory - multiple logistic regression analyses were performed to investigate associations between CHIKV infection seropositivity (presence of IgM -/or IgG to CHIKV by enzyme-linked immunoabsorbent assay) - risk factors. A total of 1154 individuals were analyzed. The overall seroprevalence of CHIKV infection was 37.2% (95% CI = 33.9-40.5), 318 (72.3%) of the seropositive participants reported symptoms consistent with a CHIKV infection during the epidemic period. Risk factors for CHIKV seropositivity among adults (aged 15 years - older) were male gender, low socioeconomic index, schooling < or = 6 years - living in makeshift housing. Our findings indicate that roughly one out of four CHIKV infections is asymptomatic. Conditions associated with poverty may be considered as critical in CHIKV acquisition. Thus, these conditions should be taken into account in the development of future prevention strategies of CHIKV disease.

Imprenta: PloS One, v. 3, n. 8, p. e3066, 2008

Identificador do objeto digital: 10.1371/journal.pone.0003066

Descritores: Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2008

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