Role of skin immune cells on the host susceptibility to mosquito-borne viruses
Autor(es): Briant Laurence, Desprès Philippe, Choumet Valérie, Missé Dorothée
Resumo: Due to climate change - the propagation of competent arthropods worldwide, arboviruses have become pathogens of major medical importance. Early transmission to vertebrates is initiated by skin puncture - deposition of virus together with arthropod saliva in the epidermis - dermis. Saliva components have the capacity to modulate skin cell responses by enhancing -/or counteracting initial replication - establishment of systemic viral infection. Here, we review the nature of the cells targeted by arboviruses at the skin level - discuss the type of cellular responses elicited by these pathogens in light of the immunomodulatory properties of arthropod vector-derived salivary factors injected at the inoculation site. Underst-ing cutaneous arbovirus-host interactions may provide new clues for the design of future therapeutics.
Palavras-Chave: Arboviruses; Chikungunya; Dengue; Innate immunity; Mosquito saliva; Rift Valley Fever; Skin; West Nile virus
Imprenta: Virology, v. 464-465, p. 26-32, 2014
Identificador do objeto digital: 10.1016/j.virol.2014.06.023
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2014
