Role of pentraxin 3 in shaping arthritogenic alphaviral disease: From enhanced viral replication to immunomodulation
Autor(es): Foo Suan-Sin, Chen Weiqiang, Taylor Adam, Sheng Kuo-Ching, Yu Xing, Teng Terk-Shin, Reading Patrick C, Blanchard Helen, Garlanda Cecilia, Mantovani Alberto, Ng Lisa F P, Herrero Lara J, Mahalingam Suresh
Resumo: The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) - Ross River virus (RRV), - the lack of antiviral treatments highlight the potential threat of a global alphavirus p-emic. The immune responses underlying alphavirus virulence remain enigmatic. We found that pentraxin 3 (PTX3) was highly expressed in CHIKV - RRV patients during acute disease. Overt expression of PTX3 in CHIKV patients was associated with increased viral load - disease severity. PTX3-deficient (PTX3(-/-)) mice acutely infected with RRV exhibited delayed disease progression - rapid recovery through diminished inflammatory responses - viral replication. Furthermore, binding of the N-terminal domain of PTX3 to RRV facilitated viral entry - replication. Thus, our study demonstrates the pivotal role of PTX3 in shaping alphavirus-triggered immunity - disease - provides new insights into alphavirus pathogenesis.
Imprenta: PLoS Pathogens, v. 11, n. 2, p. e1004649, 2015
Identificador do objeto digital: 10.1371/journal.ppat.1004649
Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya virus - Real Time PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology
Data de publicação: 2015
