Autor(es): Bhonde R R, Wagh U V, Gupta N P

Resumo: Employing Hoorn's technique, tracheal explant cultures were set from adult hamsters, rabbits - human foetuses. To determine the susceptibility of these cultures they were infected with nine different mainly non-respiratory viruses. Assay of virus was carried out in susceptible cell lines. The results of these studies indicated that herpes simplex type I (HSV-1) - vaccinia viruses multiplied in these cultures - caused ciliostasis. Herpes simplex type 2 (HSV-2) although multiplying in all, produced ciliostasis only in human foetal tracheal cultures. However, Ch-ipura (CHP), West Nile (WN), s-fly fever (SF-N) - polio-1 viruses multiplied without ciliostasis. These cultures did not support multiplication of Japanese encephalitis (JE) - Chikungunya (CHIK) viruses. The studies indicated that mammalian tracheal cultures support replication of the non-respiratory viruses. The continued - undiminished multiplication of viruses over long periods without ciliostasis suggests a role for the trachea in the transmission of viral infections by aerosol.

Imprenta: British Journal of Experimental Pathology, v. 64, n. 1, p. 1-5, 1983

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever

Data de publicação: 1983

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