Replication of alphaviruses: A review on the entry process of alphaviruses into cells
Autor(es): Leung Jason Yat-Sing, Ng Mary Mah-Lee, Chu Justin Jang Hann
Resumo: Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-str-ed, positive-sense, RNA genome. Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans. Their potential threat to human health was most recently exemplified by the 2005 Chikungunya virus outbreak in La Reunion, highlighting the necessity to underst- events in the life-cycle of these medically important human pathogens. The replication - propagation of viruses is dependent on entry into permissive cells. Viral entry is initiated by attachment of virions to cells, leading to internalization, - uncoating to release genetic material for replication - propagation. Studies on alphaviruses have revealed entry via a receptor-mediated, endocytic pathway. In this paper, the different stages of alphavirus entry are examined, with examples from Semliki Forest virus, Sindbis virus, Chikungunya virus, - Venezuelan equine encephalitis virus described.
Imprenta: Advances in Virology, v. 2011, p. 249640, 2011
Identificador do objeto digital: 10.1155/2011/249640
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Genome ; Chikungunya virus - RNA ; Chikungunya Virus - Virus
Data de publicação: 2011
