Autor(es): Kumarasamy V, Prathapa S, Zuridah H, Chem Y K, Norizah I, Chua K B

Resumo: An outbreak of Chikugunya (CHIK) fever occurred among the fishing community in Bagan Pancor, Perak. The outbreak was laboratory confirmed within 48 hours after the receipt of the specimens. Fifty-three patients' serum samples were submitted for laboratory investigation - 47 (88.7%) were confirmed to be positive for CHIK infection by RT-PCR, -/or virus isolation, -/or in-house immunoflourescent test. RT-PCR - virus isolation were the tests of choice for patients with illness of four days or less - detection of CHIK specific IgM for those with more than four days of fever. The nucleic acid sequence based on the 354- - 294-bp of the nsP1 - E1 genes of the CHIK virus detected from pools of adults Aedes aegypti mosquitoes were identical to those CHIKV virus isolated from humans in the same locality. Phylogenetic analysis of the CHIK virus based on the 257 nts partial E1 gene indicates that Bagan Panchor's strain was closely related to the first CHIK virus isolated during the outbreak in Klang in 1998.

Palavras-Chave: Chikungunya, Outbreak, Malaysia

Imprenta: The Medical Journal of Malaysia, v. 61, n. 2, p. 221-225, 2006

Descritores: Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya virus - PCR detection ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2006

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