Re-emergence of Chikungunya and O'nyong-nyong viruses: Evidence for distinct geographical lineages and distant evolutionary relationships
Autor(es): Powers A M, Brault A C, Tesh R B, Weaver S C
Resumo: Chikungunya (CHIK) virus is a member of the genus Alphavirus in the family TOGAVIRIDAE: Serologically, it is most closely related to o'nyong-nyong (ONN) virus - is a member of the Semliki Forest antigenic complex. CHIK virus is believed to be enzootic throughout much of Africa - historical evidence indicates that it spread to other parts of the world from this origin. Strains from Africa - Asia are reported to differ biologically, indicating that distinct lineages may exist. To examine the relatedness of CHIK - ONN viruses using genetic data, we conducted phylogenetic studies on isolates obtained throughout Africa - Southeast Asia. Analyses revealed that ONN virus is indeed distinct from CHIK viruses, - these viruses probably diverged thous-s of years ago. Two distinct CHIK virus lineages were delineated, one containing all isolates from western Africa - the second comprising all southern - East African strains, as well as isolates from Asia. Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa - subsequently was introduced into Asia. Within the eastern Africa - southern Africa/Asia lineage, Asian strains grouped together in a genotype distinct from the African groups. These different geographical genotypes exhibit differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquito vectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with AE: furcifer - AE: africanus mosquitoes.
Imprenta: The Journal of General Virology, v. 81, Pt 2, p. 471-479, 2000
Identificador do objeto digital: 10.1099/0022-1317-81-2-471
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - DNA ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Public health
Data de publicação: 2000
