Quantitative aspects of interferon-induced plaque reduction: Kinetics of interferon action
Autor(es): Jordan G W
Resumo: The effects of Interferon concentration and duration of exposure on the cellular resistance developed to vesicular stomatitis virus has been studied for chick and mouse interferons by the plaque reduction method. It was found that the slope of the dose-response is independent of the duration of exposure to Interferon in cells of the same age. In addition, the rate of development of resistance with time was shown to be independent of the concentration of Interferon to which the cells were exposed. A quantitative relationship between concentration, duration of exposure, and antiviral resistance is described for the period of developing resistance. The implications of these findings for the mechanism of action of interferon and for practical aspects of the plaque reduction assay are discussed.
Imprenta: Virology, v. 48, n. 2, p. 425-432, 1972
Identificador do objeto digital: 10.1016/0042-6822(72)90053-0
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 1972
