Autor(es): Puttamallesh Vinuth N, Sreenivasamurthy Sreelakshmi K, Singh Pradeep Kumar, Harsha H C, Ganjiwale Anjali, Broor Shobha, Pandey Akhilesh, Narayana Jayasuryan, Prasad T S Keshava

Resumo: Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-str-ed RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis - host responses in individuals infected with the chikungunya virus are not well understood at the molecular level. We carried out proteomic profiling of serum samples from chikungunya patients in order to identify molecules associated with the host response to infection by this virus. Proteomic profiling of serum obtained from the infected individuals resulted in identification of 569 proteins. Of these, 63 proteins were found to be differentially expressed (? 2-fold) in patient as compared to control sera. These differentially expressed proteins were involved in various processes such as lipid metabolism, immune response, transport, signal transduction - apoptosis. This is the first report providing a global proteomic profile of serum samples from individuals infected with the chikungunya virus. Our data provide an insight into the proteins that are involved as host response factors during an infection. These proteins include clusterin, apolipoproteins - S100A family of proteins.

Palavras-Chave: iTRAQ; Quantitative proteomics; Arthritis; Hyponatremia; Neuropathology

Imprenta: Clinical Proteomics, v. 10, n. 1, p. 14, 2013

Identificador do objeto digital: 10.1186/1559-0275-10-14

Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Immune response ; Chikungunya Virus - Virus

Data de publicação: 2013

INDICADORES

ACESSO