Protective and pathogenic responses to Chikungunya virus infection
Autor(es): Long Kristin M, Heise Mark T
Resumo: Chikungunya virus (CHIKV) is an arbovirus responsible for causing epidemic outbreaks of human disease characterized by painful - often debilitating arthralgia. Recently CHIKV has moved into the Caribbean - the Americas resulting in massive outbreaks in naïve human populations. Given the importance of CHIKV as an emerging disease, a significant amount of effort has gone into interpreting the virus-host interactions that contribute to protection or virus-induced pathology following CHIKV infection, with the long term goal of using this information to develop new therapies or safe - effective anti-CHIKV vaccines. This work has made it clear that numerous distinct host responses are involved in the response to CHIKV infection, where some aspects of the host innate - adaptive immune response protect from or limit virus-induced disease, while other pathways actually exacerbate the virus-induced disease process. This review will discuss mechanisms that have been identified as playing a role in the host response to CHIKV infection - illustrate the importance of carefully evaluating these responses to determine whether they play a protective or pathologic role during CHIKV infection.
Palavras-Chave: Chikungunya virus; Alphavirus; Immunopathology; Vaccine
Imprenta: Current Tropical Medicine Reports, v. 2, n. 1, p. 13-21, 2015
Identificador do objeto digital: 10.1007/s40475-015-0037-z
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cytopathology ; Chikungunya virus - Immune response ; Chikungunya virus - Immune response ; Chikungunya virus - Immunopathology ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology
Data de publicação: 2015
