Autor(es): Couderc Thérèse, Khandoudi Nassirah, Grandadam Marc, Visse Catherine, Gangneux Nicolas, Bagot Sébastien, Prost Jean-François, Lecuit Marc

Resumo: Chikungunya virus (CHIKV) is a recently reemerged arbovirus responsible for a massive outbreak of infection in the Indian Ocean region - India that has a very significant potential to spread globally because of the worldwide distribution of its mosquito vectors. CHIKV induces a usually self-limited disease in humans that is characterized by fever, arthralgia, myalgia, - rash; however, cases of severe CHIKV infection have recently been described, particularly in adults with underlying condition - neonates born to viremic mothers. Human polyvalent immunoglobulins were purified from plasma samples obtained from donors in the convalescent phase of CHIKV infection, - the preventive - curative effects of these immunoglobulins were investigated in 2 mouse models of CHIKV infection that we developed. CHIKV immunoglobulins contain anti-CHIKV antibodies - exhibit a high in vitro neutralizing activity - a powerful prophylactic - therapeutic efficacy against CHIKV infection in vivo, including in the neonate. Administration of CHIKV immunoglobulins may constitute a safe - efficacious prevention strategy - treatment for individuals exposed to CHIKV who are at risk of severe infection, such as neonates born to viremic mothers - adults with underlying conditions. These results provide a proof-of-concept for purifying human immunoglobulins from plasma samples from patients in the convalescent phase of an emerging infectious disease for which neither prevention nor treatment is available.

Imprenta: The Journal of Infectious Diseases, v. 200, n. 4, p. 516-523, 2009

Identificador do objeto digital: 10.1086/600381

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology

Data de publicação: 2009

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