Autor(es)Kading Rebekah C, Borland Erin M, Cranfield Mike, Powers Ann M

ResumoVector-borne - zoonotic pathogens have comprised a significant proportion of the emerging infectious diseases in humans in recent decades. The role of many wildlife species as reservoirs for arthropod-borne viral pathogens is poorly understood. We investigated the exposure history of various African wildlife species from the Congo basin to mosquito-borne flaviviruses - alphaviruses by testing archived serum samples. Sera from 24 African forest buffalo (Syncerus caffer nanus), 34 African elephants (Loxodonta africana), 40 duikers (Cephalophus - Philantomba spp.), 25 m-rills (M-rillus sphinx), 32 mountain gorillas (Gorilla beringei beringei), five Grauer's gorillas (Gorilla beringei graueri), two L'Hoest's monkeys (Cercopithecus lhoesti), two golden monkeys (Cercopithecus k-ti), - three chimpanzees (Pan troglodytes) sampled between 1991 - 2009 were tested for antibodies against chikungunya virus (CHIKV), o'nyong-nyong virus (ONNV), West Nile virus (WNV), dengue 2 virus (DENV-2), - yellow fever virus (YFV) by plaque reduction neutralization test. Specific neutralizing antibodies against ONNV were found in African forest buffalo in the Democratic Republic of the Congo (DRC) - Gabon, duikers in the DRC, - m-rills in Gabon, providing novel evidence of enzootic circulation of ONNV in these countries. African forest buffalo in the DRC - Gabon also demonstrated evidence of exposure to CHIKV, WNV, - DENV-2, while m-rills in Gabon were antibody positive for CHIKV, DENV-2, WNV, - YFV. All of the elephants tested had a strong neutralizing antibody response to WNV. We also document results from a survey of gorillas for arboviruses, of which 4/32 (13%) had antibody to an alphavirus or flavivirus. Overall, our results demonstrate a high prevalence of neutralizing antibodies against multiple arboviruses in wildlife in equatorial Africa.

Palavras-ChaveArbovirus; Congo basin; Emerging viruses; Primates; Surveillance; Wildlife

ImprentaJournal of Wildlife Diseases, v. 49, n. 3, p. 587-599, 2013

DescritoresChikungunya virus - Arbovirus ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação:2013