Autor(es): Cui Jin, Gao Ming, Ren Xiaofeng

Resumo: The periodic - recent outbreaks of endemic Chikungunya virus (CHIKV) infection have jeopardized the public health in wider geographical regions. Particularly, full genome-based phylogenetic analyses - recombination of CHIKV have rarely been reported. In this study, phylogenetic - recombination analyses were performed on 122 complete CHIKV genomes. Three major phylogroups were identified which included West African genotype (group I); Asian genotype (group II) as well as ESCA - Indian Ocean genotype (group III). The latter was divided into three subgroups: East/South/Central African subgroup (IIIa - b) - Indian Ocean - Asian subgroup (IIIc). Re-emerging of the CHIKV in Asian countries gave rise to a novel subgroup. Two potential recombination events were found; nevertheless, neither of both was supported by further phylogenetic - statistical analyses. These data refine the phylogeny of the currently available CHIKVs - homologous recombination did not contribute to the genetic diversity of these viruses.

Palavras-Chave: Chikungunya virus; Phylogeny; Homologous recombination

Imprenta: Infection, Genetics and Evolution, v. 11, n. 8, p. 1957-1963, 2011

Identificador do objeto digital: 10.1016/j.meegid.2011.08.026

Descritores: Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Public health

Data de publicação: 2011