Autor(es): Chow Angela, Her Zhisheng, Ong Edward K S, Chen Jinandmiao, Dimatatac Frederico, Kwek Dyan J C, Barkham Timothy, Yang Henry, Rénia Laurent, Leo Yee-Sin, Ng Lisa F P

Resumo: Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines - chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients. A case-control longitudinal study was performed that involved 30 adult patients with laboratory-confirmed Chikungunya fever. Their profiles of clinical disease, viral load, - immune mediators were investigated. When patients were segregated into high viral load - low viral load groups during the acute phase, those with high viremia had lymphopenia, lower levels of monocytes, neutrophilia, - signs of inflammation. The high viral load group was also characterized by a higher production of pro-inflammatory cytokines, such as interferon-? - interleukin (IL)-6, during the acute phase. As the disease progressed to the chronic phase, IL-17 became detectable. However, persistent arthralgia was associated with higher levels of IL-6 - granulocyte macrophage colony-stimulating factor, whereas patients who recovered fully had high levels of Eotaxin - hepatocyte growth factor. The level of CHIKV viremia during the acute phase determined specific patterns of pro-inflammatory cytokines, which were associated with disease severity. At the chronic phase, levels of IL-6, - granulocyte macrophage colony-stimulating factor found to be associated with persistent arthralgia provide a possible explanation for the etiology of arthralgia that plagues numerous CHIKV-infected patients.

Imprenta: The Journal of Infectious Diseases, v. 203, n. 2, p. 149-157, 2011

Identificador do objeto digital: 10.1093/infdis/jiq042

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2011