Perceived morbidity and community burden after a Chikungunya outbreak: The TELECHIK survey, a population-based cohort study
Autor(es): Gérardin Patrick, Fianu Adrian, Malvy Denis, Mussard Corinne, Boussaïd Karim, Rollot Olivier, Michault Alain, Gaüzere Bernard-Alex, Bréart Gérard, Favier François
Resumo: Persistent disabilities are key manifestations of Chikungunya virus (CHIKV) infection, especially incapacitating polyarthralgia - fatigue. So far, little is known about their impact on health status. The present study aimed at describing the burden of CHIKV prolonged or late-onset symptoms on the self-perceived health of La Réunion isl-ers. At 18 months after an outbreak of Chikungunya virus, we implemented the TELECHIK survey; a retrospective cohort study conducted on a r-om sample of the representative SEROCHIK population-based survey. A total of 1,094 subjects sampled for CHIKV-specific IgG antibodies in the setting of La Réunion isl- in the Indian Ocean, between August 2006 - October 2006, were interviewed about current symptoms divided into musculoskeletal/rheumatic, fatigue, cerebral, sensorineural, digestive - dermatological categories. At the time of interview, 43% of seropositive (CHIK+) subjects reported musculoskeletal pain (vs 17% of seronegative (CHIK-) subjects, P < 0.001), 54% fatigue (vs 46%, P = 0.04), 75% cerebral disorders (vs 57%, P < 0.001), 49% sensorineural impairments (vs 37%, P = 0.001), 18% digestive complaints (vs 15%, P = 0.21), - 36% skin involvement (vs 34%, P = 0.20) on average 2 years after infection (range: 15-34 months). After controlling for confounders such as age, gender, body mass index or major comorbidities in different Poisson regression models, 33% of joint pains were attributable to CHIKV, 10% of cerebral disorders - 7.5% of sensorineural impairments, while Chikungunya did not enhance fatigue states, digestive - skin disorders. On average, 2 years after infection 43% to 75% of infected people reported prolonged or late-onset symptoms highly attributable to CHIKV. These manifestations carry a significant burden in the community in the fields of rheumatology, neurology - sensorineural health.
Imprenta: BMC Medicine, v. 9, n. 5, 2011
Identificador do objeto digital: 10.1186/1741-7015-9-5
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2011
